ABSTRACT
Objective To investigate the pathogenesis, distribution of the pathogens and resistance pattern of nosocomial pneumonia in patients with diseases of central nervous system(CNS).Methods Bacterial typing was conducted on the 59 strains separated from the sputum of 59 patients of nosocomial pneumonia with CNS diseases in our hospital in 2002.MIC drug sensitive test in vitro was conducted with the most common 15 antibiotics.Results The most common pathogens of nosocomial pneumonia in the diseases of CNS were:Staphylococcus aureus 23.7%,Pseudomonas aeruginosa 22.0%,Acinetobacter baumannii 18.6%,Klebsiella pneumoniae 8.5% Xanthomonas maltophilia 6.8%?According to the drug sensitive test,antimicrobial-resistant gram-negative bacilli were increasing.None of the vancomycin-resistant MRSA variant was seen.Conclusion The risk factors of nosocomial pneumonia in the diseases of CNS are long hospital stay,respiratory tract invasive operation and unreasonable antibiotic therapy.The most common pathogens were Staphylococcus aureus,Pseudomonas aeruginosa,Acinetobacter baumannii,Klebsiella pneumoniae and Xanthomonas maltophilia.Effective and infection-control procedures,surveillance systems and appropriate antimicrobial selection are key methods in limiting nosocomial pneumonia and antimicrobial-resistant pathogen occurrence.